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The Uffizi, (1560-1580) was originally meant to be an Ufficio (office) for magistrates as well as judges, technicians and merchants of Florence, the top floor was turned into a private gallery for the pleasure of the ruling family of Florence, the Medici, and their guests. In addition to paintings, statues, jewelry, scientific instruments, even weapons,were displayed there, which made it one of the most interesting and precious collections in the whole world. Since 1865 it became a museum, nowadays with 50 rooms housing paintings ranging from the 13th century to the 18th century. The highlights are the famous “Madonna enthroned” by Giotto, the “Battle of San Romano” by Paolo Uccello, the double portrait by Piero della Francesca, “Federico da Montefeltro”, the “Birth of Venus” by Botticelli , in addition to three works by Leonardo, one by Michelangelo, a few by Raffaello and many by Tiziano. All paintings have been displayed chronologically, so it is possible to fully appreciated all the innovations in art throughout the centuries.

The Boboli Gardens (Italian: Giardini di Boboli) is a park in Florence, Italy, that is home to a collection of sculptures dating from the 16th through the 18th centuries, with some Roman antiquities. The Gardens, behind the Pitti Palace, the main seat of the Medici grand dukes of Tuscany at Florence, are some of the first and most familiar formal 16th-century Italian gardens. The mid-16th-century garden style, as it was developed here, incorporated longer axial developments, wide gravel avenues, a considerable "built" element of stone, the lavish employment of statuary and fountains, and a proliferation of detail, coordinated in semi-private and public spaces that were informed by classical accents: grottos, nympheums, garden temples and the like. The openness of the garden, with an expansive view of the city, was unconventional for its time. The gardens were very lavish, considering no access was allowed outside the immediate Medici family, and no entertainment or parties ever took place in the gardens.

The Basilica di Santa Maria del Fiore (English: Basilica of Saint Mary of the Flower) is the main church of Florence, Italy. Il Duomo di Firenze, as it is ordinarily called, was begun in 1296 in the Gothic style to the design of Arnolfo di Cambio and completed structurally in 1436 with the dome engineered by Filippo Brunelleschi. The exterior of the basilica is faced with polychrome marble panels in various shades of green and pink bordered by white and has an elaborate 19th-century Gothic Revival façade by Emilio De Fabris. The cathedral complex, located in Piazza del Duomo, includes the Baptistery and Giotto's Campanile. The three buildings are part of the UNESCO World Heritage Site covering the historic centre of Florence and are a major attraction to tourists visiting the region of Tuscany. The basilica is one of Italy's largest churches, and until development of new structural materials in the modern era, the dome was the largest in the world. It remains the largest brick dome ever constructed. The cathedral is the mother church of the Roman Catholic Archdiocese of Florence, whose archbishop is currently Giuseppe Betori.

The Palazzo Pitti in English sometimes called the Pitti Palace, is a vast mainly Renaissance palace in Florence, Italy. It is situated on the south side of the River Arno, a short distance from the Ponte Vecchio. The core of the present palazzo dates from 1458 and was originally the town residence of Luca Pitti, an ambitious Florentine banker. The palace was bought by the Medici family in 1549 and became the chief residence of the ruling families of the Grand Duchy of Tuscany. It grew as a great treasure house as later generations amassed paintings, plates, jewelry and luxurious possessions. In the late 18th century, the palazzo was used as a power base by Napoleon, and later served for a brief period as the principal royal palace of the newly united Italy. The palace and its contents were donated to the Italian people by King Victor Emmanuel III in 1919, and its doors were opened to the public as one of Florence's largest art galleries. Today, it houses several minor collections in addition to those of the Medici family, and is fully open to the public.